cerebral artery — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4330	CaCCinh-A01		Chloride channel
	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).		Chloride channel
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T6951	Pramipexole dihydrochloride hydrate	Pramipexole 2HCl Monohydrate,Mirapex	Dopamine Receptor
	Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...		Dopamine Receptor
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T37709	2,2,2-Trichloroethanol		Potassium Channel , Endogenous Metabolite
	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical ...		Potassium Channel , Endogenous Metabolite
T70540	Pinokalant	LOE-908	SARS-CoV , TRP/TRPV Channel
	Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem...		SARS-CoV , TRP/TRPV Channel
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T19478	Nicotinoyl cyclandelate	RV 12128	Others
	Nicotinoyl cyclandelate can effectively reduce blood pressure in the femoral artery and perfusion pressure in cerebral blood vessels.		Others
T16902	SMND-309		Others
	SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.		Others
T2S0118	Daurinoline		Calcium Channel , 5-HT Receptor , Histamine Receptor
	Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mat...		Calcium Channel , 5-HT Receptor , Histamine Receptor
T26665	AS604872	AS-604872,AS 604872
	AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic l...
T28414	Piclozotan	SUN-N-4057,SUN4057,SUNN-4057,SUN-4057,SUNN4057	5-HT Receptor
	Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advan...		5-HT Receptor
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ...
TN3323	Monomethyl lithospermate	Lithospermic acid monomethyl ester	Akt , PI3K
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and pro...		Akt , PI3K
T81451	PKCd (8-17)
	PKCd (8-17) is a bioactive peptide originating from the V1 domain of protein kinase C (PKC)d. It impedes phorbol 12-myristate 13-acetate (PMA)-stimulated PKCd translocation and activation, which mitigates ischemic injury...
T83777	LAU-0901
	LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ...
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...
T83695	MOG Peptide (human, bovine) acetate	Myelin Oligodendrocyte Glycoprotein Peptide
	Myelin oligodendrocyte glycoprotein (MOG) peptide, a truncated form of MOG located on the extracellular myelin sheath surface, interacts with antigen serotype HLA-DR2 to mitigate effects of ischemic stroke induced by mid...